Long term therapy (>6 months) of nitrofurantoin can lead to diffuse interstitial pneumonitis, pulmonary fibrosis, chronic hepatitis, and neuropathy. The choice of antibiotic depends on community patterns of resistance and patient-specific factors (eg, prior efficacy, cost) as no specific therapy is present. Note: Prophylaxis may be considered in nonpregnant women with recurrent uncomplicated cystitis despite non-antimicrobial preventive measures. Nitrofurantoin Dose in the prophylaxis of recurrent Cystitis:
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